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Article

Abnormal neurovascular coupling as a cause of excess cerebral vasodilation in familial migraine.

Cardiovascular research - 1 Oct 2020

Staehr Christian, Rajanathan Rajkumar, Postnov Dmitry D, Hangaard Lise, Bouzinova Elena V, Lykke-Hartmann Karin, Bach Flemming W, Sandow Shaun L, Aalkjaer Christian, Matchkov Vladimir V

Abstract excerpt

AIMS: Acute migraine attack in familial hemiplegic migraine type 2 (FHM2) patients is characterized by sequential hypo- and hyperperfusion. FHM2 is associated with mutations in the Na, K-ATPase α2 isoform. Heterozygous mice bearing one of these mutations (α2+/G301R mice) were shown to have elevated cerebrovascular tone and, thus, hypoperfusion that might lead to elevated concentrations of local metabolites. We...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

Identifiers

PMID: 31710670
DOI: 10.1093/cvr/cvz306

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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