Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Single-cell multiomics reveals the complexity of TGFβ signalling to chromatin in iPSC-derived kidney organoids

27 Nov 2022

Abstract excerpt

Abstract TGFβ1 plays a regulatory role in the determination of renal cell fate and the progression of renal fibrosis. Here we show an association between SMAD3 and the histone methyltransferase, EZH2, during cell differentiation; ChIP-seq revealed that SMAD3 and EZH2 co-occupy the genome in iPSCs and in iPSC-derived nephron progenitors. Through integration of single cell gene expression and epigenome profiling,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Chronic Kidney Disease and Diabetes
Share to Renal and related cancers
Share to Renal cell carcinoma treatment

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 36435939
DOI: 10.1038/s42003-022-04264-1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Single-cell multiomics reveals the complexity of TGFβ signalling to chromatin in iPSC-derived kidney organoidsPMID 36435939Read ↗

Single cell resolution regulatory landscape of the mouse kidney highlights cellular differentiation programs and renal disease targetsSemantic proximity Read ↗

Identification of a core transcriptional program driving the human renal mesenchymal-to-epithelial transitionSemantic proximity Read ↗

Single cell regulatory landscape of the mouse kidney highlights cellular differentiation programs and disease targets.Semantic proximity Read ↗

Single-cell chromatin and gene-regulatory dynamics of mouse nephron progenitorsSemantic proximity Read ↗

Identification of a core transcriptional program driving the human renal mesenchymal-to-epithelial transitionSemantic proximity Read ↗

Decoding myofibroblast origins in human kidney fibrosisSemantic proximity Read ↗

Scissor–CIBERSORTx Deconvolution Reveals Functional Heterogeneity of CTAL/aTAL Cells and Associated Biomarkers in Renal FibrosisSemantic proximity Read ↗

Transcriptional regulatory control of mammalian nephron progenitors revealed by multi-factor cistromic analysis and genetic studiesSemantic proximity Read ↗

An EZH2-dependent transcriptional complex promotes aberrant epithelial remodelling after injurySemantic proximity Read ↗

Fibrosis—the tale of H3K27 histone methyltransferases and demethylasesSemantic proximity Read ↗

Emerging Transcriptional Mechanisms in the Regulation of Epithelial to Mesenchymal Transition and Cellular Plasticity in the KidneySemantic proximity Read ↗

Dynamic multi-omics and mechanistic modeling approach uncovers novel mechanisms of kidney fibrosis progressionSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.