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Article

SHROOM3 is a novel candidate for heterotaxy identified by whole exome sequencing.

Genome biology - 21 Sept 2011

Tariq Muhammad, Belmont John W, Lalani Seema, Smolarek Teresa, Ware Stephanie M

Abstract excerpt

BACKGROUND: Heterotaxy-spectrum cardiovascular disorders are challenging for traditional genetic analyses because of clinical and genetic heterogeneity, variable expressivity, and non-penetrance. In this study, high-resolution SNP genotyping and exon-targeted array comparative genomic hybridization platforms were coupled to whole-exome sequencing to identify a novel disease candidate gene. RESULTS: SNP genotyping...

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Source

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Identifiers

PMID: 21936905
DOI: 10.1186/gb-2011-12-9-r91
PMCID: PMC3308054

Genes

SHROOM3
CTSO
CXCL2
ROCK2
RXFP1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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