Article

Maturation and detoxification of synphilin-1 inclusion bodies regulated by sphingolipids

2023-09-27

Abstract excerpt

Due to proteostasis stress induced by aging or disease, misfolded proteins can form toxic intermediate species of aggregates and eventually mature into less toxic inclusion bodies (IBs). Here, using a yeast imaging-based screen, we identified 84 potential synphilin-1 (SY1) IB regulators and isolated the conserved sphingolipid metabolic components in the most enriched groups. Furthermore, we show that, in both yeas...

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Literature Corpus work: ac354d46-85ce-59da-a050-ddfa99d8a4c9
DOI: 10.1101/2023.09.27.559647

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