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Regulation of steady state ribosomal transcription in Mycobacterium tuberculosis: Intersection of sigma subunits, superhelicity, and transcription factors

12 Jun 2025

Abstract excerpt

Ribosomal RNA (rRNA) regulation in Mycobacterium tuberculosis ( Mtb ) is tightly linked to nutrient availability, growth phase, and global gene expression, influencing Mtb's adaptability and pathogenicity. Unlike most bacteria, Mtb has a single ribosomal operon with two promoters, rrnA P3 and rrnA P1, and a high ratio of sigma (σ) factors to genome size. While σ A is the primary driver of ribosomal transcription,...

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PMID: 40516872
DOI: 10.1016/j.jbc.2025.110369

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