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Article

Mycobacterium tuberculosis RNA polymerase-binding protein A (RbpA) and its interactions with sigma factors.

The Journal of biological chemistry - 17 May 2013

Bortoluzzi Alessio, Muskett Frederick W, Waters Lorna C, Addis Philip W, Rieck Barbara, Munder Thomas, Schleier Susanne, Forti Francesca, Ghisotti Daniela, Carr Mark D, O'Hare Helen M

Abstract excerpt

RNA polymerase-binding protein A (RbpA), encoded by Rv2050, is specific to the actinomycetes, where it is highly conserved. In the pathogen Mycobacterium tuberculosis, RbpA is essential for growth and survival. RbpA binds to the β subunit of the RNA polymerase where it activates transcription by unknown mechanisms, and it may also influence the response of M. tuberculosis to the current frontline...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Identifiers

PMID: 23548911
DOI: 10.1074/jbc.M113.459883
PMCID: PMC3656299

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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