Article

Chaperone-mediated stress-sensing in <i>Mycobacterium tuberculosis</i> enables fast activation and sustained response

2020-06-05

Abstract excerpt

<h4>ABSTRACT</h4> Dynamical properties of gene-regulatory networks are tuned to ensure bacterial survival. In mycobacteria, MprAB- σ E network responds to the presence of stressors, such as surfactants causing surface stress. Positive feedback loops in this network were previously predicted to cause hysteresis, i.e. different responses to identical stressor levels for pre-stressed and unstressed cells. Here we...

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Literature Corpus work: ac32299c-70f6-5685-a2ff-b83754fe3775
DOI: 10.1101/2020.06.04.135335

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