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Article

Structural transitions in the transcription elongation complexes of bacterial RNA polymerase during σ-dependent pausing.

Nucleic acids research - 1 Apr 2012

Zhilina Ekaterina, Esyunina Daria, Brodolin Konstantin, Kulbachinskiy Andrey

Abstract excerpt

A transcription initiation factor, the σ(70) subunit of Escherichia coli RNA polymerase (RNAP) induces transcription pausing through the binding to a promoter-like pause-inducing sequence in the DNA template during transcription elongation. Here, we investigated the mechanism of σ-dependent pausing using reconstituted transcription elongation complexes which allowed highly efficient and precisely controlled pause...

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Identifiers

PMID: 22140106
DOI: 10.1093/nar/gkr1158
PMCID: PMC3326312

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