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Regulation of Steady State Ribosomal Transcription in <i>Mycobacterium tuberculosis</i> : Intersection of Sigma Subunits, Superhelicity, and Transcription Factors

2025-02-27

Abstract excerpt

<h4>ABSTRACT</h4> The regulation of ribosomal RNA (rRNA) is closely tied to nutrient availability, growth phase, and global gene expression, serving as a key factor in bacterial adaptability and pathogenicity. Mycobacterium tuberculosis (Mtb ) stands out from other species with a single ribosomal operon controlled by two promoters: rrnA P3 and rrnA P1 and a high ratio of sigma (σ) factors to genome size. While...

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Literature Corpus work
e5378c5e-2a77-5d83-8675-c4b3f40fde37
DOI
10.1101/2025.02.24.639987
Open publication

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Regulation of Steady State Ribosomal Transcription in <i>Mycobacterium tuberculosis</i> : Intersection of Sigma Subunits, Superhelicity, and Transcription FactorsDOI 10.1101/2025.02.24.639987
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