Article
Parallel signaling through IRE1α and PERK regulates pancreatic neuroendocrine tumor growth and survival
2019-01-16
Abstract excerpt
Master regulators of the unfolded protein response (UPR)—IRE1α and PERK— promote adaptation or apoptosis depending on levels of endoplasmic reticulum (ER) stress. While the UPR is activated in many cancers, its effects on tumor growth remain unclear. Derived from endocrine cells, pancreatic neuroendocrine tumors (PanNETs) universally hypersecrete one or more peptide hormones, likely sensitizing these cells to high...
Topics
Open a Topic to create a Post that cites this publication.
Identifiers and source
- Literature Corpus work
- 9d74308a-b3f2-5aef-bfd2-532e74f19803
- DOI
- 10.1101/522102