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Impact of Obesity-Related Endoplasmic Reticulum Stress on Cancer and Associated Molecular Targets

3 Apr 2024

Abstract excerpt

Obesity, characterized by excessive body fat, is closely linked to endoplasmic reticulum (ER) stress, leading to insulin resistance and type 2 diabetes. Inflammatory pathways like c-Jun N-terminal kinase (JNK) worsen insulin resistance, impacting insulin signaling. Moreover, ER stress plays a substantial role in cancer, influencing tumor cell survival and growth by releasing factors like vascular endothelial...

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PMID: 38672148
DOI: 10.3390/biomedicines12040793

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