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How the Unfolded Protein Response Is a Boon for Tumors and a Bane for the Immune System

1 Apr 2023

Abstract excerpt

The correct folding of proteins is essential for appropriate cell function and is tightly regulated within the endoplasmic reticulum (ER). Environmental challenges and cellular conditions disrupt ER homeostasis and induce ER stress, which adversely affect protein folding and activate the unfolded protein response (UPR). It is now becoming recognized that cancer cells can overcome survival challenges posed within...

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PMID: 37067519
DOI: 10.4049/immunohorizons.2200064

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