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Article

Current understanding of the molecular biology of pancreatic neuroendocrine tumors.

Journal of the National Cancer Institute - 17 Jul 2013

Zhang Jianliang, Francois Rony, Iyer Renuka, Seshadri Mukund, Zajac-Kaye Maria, Hochwald Steven N

Abstract excerpt

Pancreatic neuroendocrine tumors (PanNETs) are complicated and often deadly neoplasms. A recent increased understanding of their molecular biology has contributed to expanded treatment options. DNA sequencing of samples derived from patients with PanNETs and rare genetic syndromes such as multiple endocrine neoplasia type 1 (MEN1) and Von Hippel-Lindau (VHL) syndrome reveals the involvement of MEN1, DAXX/ATRX,...

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Identifiers

PMID: 23840053
DOI: 10.1093/jnci/djt135
PMCID: PMC6281020

Genes

MEN1
ATRX
DAXX
VHL

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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