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Deciphering Medulloblastoma: Epigenetic and Metabolic Changes Driving Tumorigenesis and Treatment Outcomes

4 Aug 2025

Abstract excerpt

BACKGROUND/OBJECTIVES: Medulloblastoma is the most common malignant brain tumor in children and comprises four molecular subtypes-WNT, SHH, Group 3, and Group 4-each with distinct genetic, epigenetic, and metabolic features. Increasing evidence highlights the critical role of metabolic reprogramming and epigenetic alterations in driving tumor progression, therapy resistance, and clinical outcomes. This review...

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PMID: 40868156
DOI: 10.3390/biomedicines13081898

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