Article
Increased localization of APP-C99 in mitochondria-associated ER membranes causes mitochondrial dysfunction in Alzheimer disease.
The EMBO journal - 15 Nov 2017
Pera Marta, Larrea Delfina, Guardia-Laguarta Cristina, Montesinos Jorge, Velasco Kevin R, Agrawal Rishi R, Xu Yimeng, Chan Robin B, Di Paolo Gilbert, Mehler Mark F, Perumal Geoffrey S, Macaluso Frank P, Freyberg Zachary Z, Acin-Perez Rebeca, Enriquez Jose Antonio, Schon Eric A, Area-Gomez Estela
Abstract excerpt
In the amyloidogenic pathway associated with Alzheimer disease (AD), the amyloid precursor protein (APP) is cleaved by β-secretase to generate a 99-aa C-terminal fragment (C99) that is then cleaved by γ-secretase to generate the β-amyloid (Aβ) found in senile plaques. In previous reports, we and others have shown that γ-secretase activity is enriched in mitochondria-associated endoplasmic reticulum (ER) membranes...
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