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Article

Genetic predisposition to Alzheimer's disease alters inflammasome activity after traumatic brain injury.

Translational research : the journal of laboratory and clinical medicine - 1 Jul 2023

Johnson Nathan H, Kerr Nadine A, de Rivero Vaccari Juan P, Bramlett Helen M, Keane Robert W, Dietrich W Dalton

Abstract excerpt

Traumatic Brain Injury (TBI) is a major cause of death and disability in the US and a recognized risk factor for the development of Alzheimer's disease (AD). The relationship between these conditions is not completely understood, but the conditions may share additive or synergistic pathological hallmarks that may serve as novel therapeutic targets. Heightened inflammasome signaling plays a critical role in the...

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Identifiers

PMID: 36758791
DOI: 10.1016/j.trsl.2023.02.001
PMCID: PMC10192027

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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