Article

WDR62 deficiency results in synaptic dysfunction and ASD-like behaviors in mice, which can be ameliorated by RA repletion

2022-04-01

Abstract excerpt

<h4>Background: </h4> Brain size abnormality is correlated with increased frequency of autism spectrum disorder (ASD) in offspring. Genetic analysis indicates that many heterozygous mutations of microcephaly-associated genes including WD repeat domain 62 ( WDR62 ), are associated with ASD; however, biological evidence is still lacking. <h4>Methods: </h4>: To investigate the association between WDR62 and ASD, we ge...

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Literature Corpus work: 9d48bce6-50d4-52f5-b273-e65fb46f2597
DOI: 10.21203/rs.3.rs-1491152/v1

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