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Prkn knockout mice show autistic-like behaviors and aberrant synapse formation

10 Jun 2022

Abstract excerpt

Autism spectrum disorder (ASD) is a neurodevelopmental disorder with high genetic heterogeneity, affecting one in 44 children in the United States. Recent genomic sequencing studies from autistic human individuals indicate that PARK2 , a gene that has long been considered in the pathogenesis of Parkinson's disease, is involved in ASD. Here, we report that Prkn knockout (KO) mice demonstrate autistic-like...

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PMID: 35789851
DOI: 10.1016/j.isci.2022.104573

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