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Article

Microcephaly disease gene Wdr62 regulates mitotic progression of embryonic neural stem cells and brain size.

Nature communications - 30 May 2014

Chen Jian-Fu, Zhang Ying, Wilde Jonathan, Hansen Kirk C, Lai Fan, Niswander Lee

Abstract excerpt

Human genetic studies have established a link between a class of centrosome proteins and microcephaly. Current studies of microcephaly focus on defective centrosome/spindle orientation. Mutations in WDR62 are associated with microcephaly and other cortical abnormalities in humans. Here we create a mouse model of Wdr62 deficiency and find that the mice exhibit reduced brain size due to decreased neural progenitor...

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Identifiers

PMID: 24875059
DOI: 10.1038/ncomms4885
PMCID: PMC4216695

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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