Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Lithium normalizes ASD-related neuronal, synaptic, and behavioral phenotypes in DYRK1A-knockin mice.

Molecular psychiatry - 1 Jun 2025

Roh Junyeop Daniel, Bae Mihyun, Kim Hyosang, Yang Yeji, Lee Yeunkeum, Cho Yisul, Lee Suho, Li Yan, Yang Esther, Jang Hyunjee, Kim Hyeonji, Kim Hyun, Kang Hyojin, Ellegood Jacob, Lerch Jason P, Bae Yong Chul, Kim Jin Young, Kim Eunjoon

Abstract excerpt

Dyrk1A deficiency is linked to various neurodevelopmental disorders, including developmental delays, intellectual disability (ID) and autism spectrum disorders (ASD). Haploinsufficiency of Dyrk1a in mice reportedly leads to ASD-related phenotypes. However, the key pathological mechanisms remain unclear and human DYRK1A mutations remain uncharacterized in mice. Here, we generated and studied Dyrk1a-knockin mice...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autism Spectrum Disorder Research
Share to Down syndrome and intellectual disability research

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Genetics and Neurodevelopmental Disorders

Source

Open in PubMed Open full text

Identifiers

PMID: 39633007
DOI: 10.1038/s41380-024-02865-2
PMCID: PMC12092274

Genes

DYRK1A

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 21 Oct 2026.

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Lithium normalizes ASD-related neuronal, synaptic, and behavioral phenotypes in DYRK1A-knockin mice.PMID 39633007Read ↗

Dyrk1a Mutations Cause Undergrowth of Cortical Pyramidal Neurons via Dysregulated Growth Factor Signaling.Semantic proximity Read ↗

Epigenetic treatment of synaptic and behavioral deficits in Dyrk1a-mutant mice.Semantic proximity Read ↗

DYRK1A BAC transgenic mice show altered synaptic plasticity with learning and memory defectsSemantic proximity Read ↗

Bazedoxifene rescues sexually dimorphic autistic-like abnormalities in mice carrying a biallelic <i>MDGA1</i> mutationSemantic proximity Read ↗

Prefrontal Deficits in a Murine Model Overexpressing the Down Syndrome Candidate Gene<i>Dyrk1a</i>Semantic proximity Read ↗

Prenatal treatment with rapamycin restores enhanced hippocampal mGluR-LTD and mushroom spine size in a Down’s syndrome mouse modelSemantic proximity Read ↗

Autism-associated Dyrk1a truncation mutants impair neuronal dendritic and spine growth and interfere with postnatal cortical developmentSemantic proximity Read ↗

Impaired development of neocortical circuits contributes to the neurological alterations in <i>DYRK1A</i> haploinsufficiency syndromeSemantic proximity Read ↗

Impaired development of neocortical circuits contributes to the neurological alterations in DYRK1A haploinsufficiency syndromeSemantic proximity Read ↗

Prenatal treatment with rapamycin restores enhanced hippocampal mGluR-LTD and mushroom spine size in a Down’s syndrome mouse modelSemantic proximity Read ↗

The utility of rodent models of autism spectrum disorders.Semantic proximity Read ↗

The neurodevelopmental disorder risk gene DYRK1A is required for ciliogenesis and control of brain size in Xenopus embryos.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.