Article

Altered brain structure in an ATRX-deficient mouse model of autism spectrum disorder

2025-08-06

Abstract excerpt

<h4>ABSTRACT</h4> Mutations in the ATRX gene are a primary cause of ATR-X syndrome, which is characterized by intellectual disability, autism, and a range of brain structural abnormalities, including microcephaly. We previously showed that mice with conditional ATRX ablation in forebrain excitatory neurons display deficits in fear memory and autism-related behaviors, with some effects exhibiting sexual dimorphis...

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Literature Corpus work: bd3fbbbc-fc4a-5f1d-b849-523c25b0bf38
DOI: 10.1101/2025.08.06.666605

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