Uncoupling memory impairments from autism-associated behaviors in Chd2 deficient mice.

Abstract excerpt

Mutations in the chromatin remodeler, CHD2, are strongly associated with moderate to severe intellectual disability, autism and epilepsy, but the direct contribution of CHD2 mutations to clinical phenotypes is poorly understood. We report developmental and sex-specific behavioral changes in mice carrying a heterozygous mutation in Chd2. Notably, Chd2 mutants display a range of abnormal behaviors including...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to Autistic Disorder
• Share to Behavior, Animal
• Share to Brain