Article
Disruption of the non-canonical Wnt gene PRICKLE2 leads to autism-like behaviors with evidence for hippocampal synaptic dysfunction.
Molecular psychiatry - 1 Oct 2013
Sowers L P, Loo L, Wu Y, Campbell E, Ulrich J D, Wu S, Paemka L, Wassink T, Meyer K, Bing X, El-Shanti H, Usachev Y M, Ueno N, Manak J R, Manak R J, Shepherd A J, Ferguson P J, Darbro B W, Richerson G B, Mohapatra D P, Wemmie J A, Bassuk A G
Abstract excerpt
Autism spectrum disorders (ASDs) have been suggested to arise from abnormalities in the canonical and non-canonical Wnt signaling pathways. However, a direct connection between a human variant in a Wnt pathway gene and ASD-relevant brain pathology has not been established. Prickle2 (Pk2) is a post-synaptic non-canonical Wnt signaling protein shown to interact with post-synaptic density 95 (PSD-95). Here, we show...
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