Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Heterozygous Ambra1 Deficiency in Mice: A Genetic Trait with Autism-Like Behavior Restricted to the Female Gender

16 May 2014

Abstract excerpt

Autism-spectrum disorders (ASD) are heterogeneous, highly heritable neurodevelopmental conditions affecting around 0.5% of the population across cultures, with a male/female ratio of approximately 4:1. Phenotypically, ASD are characterized by social interaction and communication deficits, restricted interests, repetitive behaviors, and reduced cognitive flexibility. Identified causes converge at the level of the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autism Spectrum Disorder Research
Share to Genetics and Neurodevelopmental Disorders
Share to Virology and Viral Diseases

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 24904333
DOI: 10.3389/fnbeh.2014.00181

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Heterozygous Ambra1 Deficiency in Mice: A Genetic Trait with Autism-Like Behavior Restricted to the Female GenderPMID 24904333Read ↗

Sexual dimorphism of AMBRA1-related autistic features in human and mouse.Semantic proximity Read ↗

Regulation of excitatory presynaptic activity by Ambra1 protein determines neuronal networks in sex-dimorphic mannerSemantic proximity Read ↗

Chemogenetic rectification of the inhibitory tone onto hippocampal neurons reverts autistic-like traits and normalizes local expression of estrogen receptors in the Ambra1+/- mouse model of female autism.Semantic proximity Read ↗

Effects of Fmr1 Gene Mutations on Sex Differences in Autism-Like Behavior and Dendritic Spine Development in Mice and Transcriptomic Studies.Semantic proximity Read ↗

Mutations in ASH1L cause a neurodevelopmental disorder with sex differences in epilepsy and autismSemantic proximity Read ↗

Ambra1 regulates autophagy and development of the nervous system.Semantic proximity Read ↗

Translational animal models of autism and neurodevelopmental disorders.Semantic proximity Read ↗

Mutations associated with autism lead to similar synaptic and behavioral alterations in both sexes of male and female mouse brain.Semantic proximity Read ↗

Advances in behavioral genetics: mouse models of autism.Semantic proximity Read ↗

[Genetic analyses for identifying molecular mechanisms in autism spectrum disorders].Semantic proximity Read ↗

Development of an autism severity score for mice using Nlgn4 null mutants as a construct-valid model of heritable monogenic autism.Semantic proximity Read ↗

A mouse model of ATRX deficiency with cognitive deficits and autistic traitsSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.