Article

Regulation of excitatory presynaptic activity by Ambra1 protein determines neuronal networks in sex-dimorphic manner

2022-12-20

Abstract excerpt

Heterozygous mutation of Ambra1 , known as a positive autophagy regulator, produces autismlike behavior in mice and autistic phenotypes in humans in a female-specific manner. However, the substantial roles of the Ambra1 mutation in neurons are still unknown. We find that Ambra1 heterozygotes display a moderate decrease in excitatory synaptic release in-vitro and ex-vivo exclusively in females without autophag...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: c4aa2f0c-0c65-5abe-960a-3f8c93c2093d
DOI: 10.1101/2022.12.19.521004

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Regulation of excitatory presynaptic activity by Ambra1 protein determines neuronal networks in sex-dimorphic mannerDOI 10.1101/2022.12.19.521004Read

Heterozygous Ambra1 Deficiency in Mice: A Genetic Trait with Autism-Like Behavior Restricted to the Female GenderSemantic proximity Read

Chemogenetic rectification of the inhibitory tone onto hippocampal neurons reverts autistic-like traits and normalizes local expression of estrogen receptors in the Ambra1+/- mouse model of female autism.Semantic proximity Read

Sexual dimorphism of AMBRA1-related autistic features in human and mouse.Semantic proximity Read

<i>Arid1b</i> haploinsufficiency in pyramidal neurons causes cellular and circuit changes in neocortex but is not sufficient to produce behavioral or seizure phenotypesSemantic proximity Read

Identification of secretory autophagy as a novel mechanism modulating activity-induced synaptic remodelingSemantic proximity Read

Mutations in ASH1L cause a neurodevelopmental disorder with sex differences in epilepsy and autismSemantic proximity Read

Ambra1 regulates autophagy and development of the nervous system.Semantic proximity Read

Loss of Rai1 enhances hippocampal excitability and epileptogenesis in mouse models of Smith-Magenis syndrome.Semantic proximity Read

Identification of secretory autophagy as a mechanism modulating activity-induced synaptic remodelingSemantic proximity Read

GABARAPs dysfunction by autophagy deficiency in adolescent brain impairs GABA A receptor trafficking and social behaviorSemantic proximity Read

Monoallelic de novo AJAP1 loss-of-function variants disrupt trans-synaptic control of neurotransmitter release.Semantic proximity Read

Glutamatergic and GABAergic neurons mediate distinct neurodevelopmental phenotypes of <i>STXBP1</i> encephalopathySemantic proximity Read