Article

Subchronic amphetamine decreases hyperactivity, anti-social behaviour and anhedonia in dopamine transporter knockout rats: role of prefrontal glutamate

2025-03-20

Abstract excerpt

<h4>Background: </h4> and Purpose: Hyperdopaminergia is a key feature of neuropsychiatric disorders including schizophrenia, attention deficit hyperactivity disorder, and bipolar disorder and can be modeled using dopamine transporter knockout (DAT KO) rats. Previous studies have shown that acute amphetamine has a paradoxical calming effect in DAT KO rats, but the effects of repeated amphetamine treatment are unkno...

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Literature Corpus work: 9d4517f5-b932-596f-9dba-e0d36f6fc249
DOI: 10.22541/au.174245788.87799595/v1

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