Article
Brain-specific overexpression of trace amine-associated receptor 1 alters monoaminergic neurotransmission and decreases sensitivity to amphetamine.
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 Nov 2012
Revel Florent G, Meyer Claas A, Bradaia Amyaouch, Jeanneau Karine, Calcagno Eleonora, André Cédric B, Haenggi Markus, Miss Marie-Thérèse, Galley Guido, Norcross Roger D, Invernizzi Roberto W, Wettstein Joseph G, Moreau Jean-Luc, Hoener Marius C
Abstract excerpt
Trace amines (TAs) such as β-phenylethylamine, p-tyramine, or tryptamine are biogenic amines found in the brain at low concentrations that have been implicated in various neuropsychiatric disorders like schizophrenia, depression, or attention deficit hyperactivity disorder. TAs are ligands for the recently identified trace amine-associated receptor 1 (TAAR1), an important modulator of monoamine neurotransmission....
Topics
- Amphetamine
- Aniline Compounds
- Animals
- Behavior, Animal
- Biogenic Monoamines
- Brain Chemistry
- Central Nervous System Stimulants
- Dopaminergic Neurons