Article
A mouse model of the schizophrenia-associated 1q21.1 microdeletion syndrome exhibits altered mesolimbic dopamine transmission.
Translational psychiatry - 30 Nov 2017
Nielsen Jacob, Fejgin Kim, Sotty Florence, Nielsen Vibeke, Mørk Arne, Christoffersen Claus T, Yavich Leonid, Lauridsen Jes B, Clausen Dorte, Larsen Peter H, Egebjerg Jan, Werge Thomas M, Kallunki Pekka, Christensen Kenneth V, Didriksen Michael
Abstract excerpt
1q21.1 hemizygous microdeletion is a copy number variant leading to eightfold increased risk of schizophrenia. In order to investigate biological alterations induced by this microdeletion, we generated a novel mouse model (Df(h1q21)/+) and characterized it in a broad test battery focusing on schizophrenia-related assays. Df(h1q21)/+ mice displayed increased hyperactivity in response to amphetamine challenge and...
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