Article
Behavioral phenotyping and dopamine dynamics in mice with conditional deletion of the glutamate transporter GLT-1 in neurons: resistance to the acute locomotor effects of amphetamine.
Psychopharmacology - 1 May 2018
Fischer Kathryn D, Houston Alex C W, Desai Rajeev I, Doyle Michelle R, Bergman Jack, Mian Maha, Mannix Rebekah, Sulzer David L, Choi Se Joon, Mosharov Eugene V, Hodgson Nathaniel W, Bechtholt Anita, Miczek Klaus A, Rosenberg Paul A
Abstract excerpt
RATIONALE: GLT-1 is the major glutamate transporter in the brain and is expressed predominantly in astrocytes but is also present in excitatory axon terminals. To understand the functional significance of GLT-1 expressed in neurons, we generated a conditional GLT-1 knockout mouse and inactivated GLT-1 in neurons using Cre-recombinase expressed under the synapsin 1 promoter, (synGLT-1 KO). OBJECTIVES:...
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