Article
Prefrontal glutamate correlates of methamphetamine sensitization and preference.
The European journal of neuroscience - 1 Mar 2016
Lominac Kevin D, Quadir Sema G, Barrett Hannah M, McKenna Courtney L, Schwartz Lisa M, Ruiz Paige N, Wroten Melissa G, Campbell Rianne R, Miller Bailey W, Holloway John J, Travis Katherine O, Rajasekar Ganesh, Maliniak Dan, Thompson Andrew B, Urman Lawrence E, Kippin Tod E, Phillips Tamara J, Szumlinski Karen K
Abstract excerpt
Methamphetamine (MA) is a widely misused, highly addictive psychostimulant that elicits pronounced deficits in neurocognitive function related to hypo-functioning of the prefrontal cortex (PFC). Our understanding of how repeated MA impacts excitatory glutamatergic transmission within the PFC is limited, as is information about the relationship between PFC glutamate and addiction vulnerability/resiliency. In vivo...
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