Article
Alterations in amphetamine-stimulated dopamine overflow due to the Nurr1-null heterozygous genotype and postweaning isolation.
Synapse (New York, N.Y.) - 1 Oct 2008
Moore Talisha M, Brown Timothy, Cade Mirae, Eells Jeffrey B
Abstract excerpt
The nuclear receptor Nurr1 functions to regulate dopamine neurotransmission, as Nurr1-null heterozygous (+/-) mice have alterations in dopamine function and, when raised in isolation immediately after weaning, have disruptions in sensorimotor gaiting, a behavior altered in schizophrenia and modulated by dopamine neurotransmission. The goal of this study was to determine nigrostriatal and mesoaccumbens dopamine...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.