Article
Alterations in amphetamine-stimulated dopamine overflow due to the Nurr1-null heterozygous genotype and postweaning isolation.
Synapse (New York, N.Y.) - 1 Oct 2008
Moore Talisha M, Brown Timothy, Cade Mirae, Eells Jeffrey B
Abstract excerpt
The nuclear receptor Nurr1 functions to regulate dopamine neurotransmission, as Nurr1-null heterozygous (+/-) mice have alterations in dopamine function and, when raised in isolation immediately after weaning, have disruptions in sensorimotor gaiting, a behavior altered in schizophrenia and modulated by dopamine neurotransmission. The goal of this study was to determine nigrostriatal and mesoaccumbens dopamine...
Topics
- Amphetamine
- Animals
- Corpus Striatum
- DNA-Binding Proteins
- Dopamine
- Dose-Response Relationship, Drug
- Genetic Carrier Screening
- Genotype
- Male
- Mice
- Mice, Knockout
- Nuclear Receptor Subfamily 4, Group A, Member 2
- Nucleus Accumbens
- Social Isolation
- Transcription Factors
- Weaning