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Article

A crucial role for forebrain adenosine A(2A) receptors in amphetamine sensitization.

Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology - 1 May 2005

Bastia Elena, Xu Yue-Hang, Scibelli Angela C, Day Yuan-Ji, Linden Joel, Chen Jiang-Fan, Schwarzschild Michael A

Abstract excerpt

Adenosine A(2A) receptors (A(2A)Rs) are well positioned to influence the maladaptive CNS responses to repeated dopaminergic stimulation in psychostimulant addiction. Expression of A(2A)Rs in brain is largely restricted to the nucleus accumbens and striatum, where molecular adaptations mediate chronic effects of psychostimulants such as behavioral sensitization. Using a novel forebrain-specific conditional...

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PMID: 15602504
DOI: 10.1038/sj.npp.1300630

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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