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Article

Positive symptom phenotypes appear progressively in "EDiPS", a new animal model of the schizophrenia prodrome.

Scientific reports - 22 Feb 2021

Petty Alice, Cui Xiaoying, Ali Asad, Du Zilong, Srivastav Sunil, Kesby James P, Kirik Deniz, Howes Oliver, Eyles Darryl

Abstract excerpt

An increase in dopamine (DA) synthesis capacity in the dorsal striatum (DS) during the prodromal stage of schizophrenia becomes more pronounced as patients progress to the full disorder. Understanding this progression is critical to intervening in disease course. We developed an animal model-Enhanced Dopamine in Prodromal Schizophrenia (EDiPS)-which uses a genetic construct to increase DA synthesis capacity in...

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Identifiers

PMID: 33619296
DOI: 10.1038/s41598-021-83681-4
PMCID: PMC7900200

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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