Article
Allosteric regulation of kinase activity in living cells
2023-07-19
Abstract excerpt
The dysregulation of protein kinases is associated with multiple diseases due to the kinases’ involvement in a variety of cell signaling pathways. Manipulating protein kinase function, by controlling the active site, is a promising therapeutic and investigative strategy to mitigate and study diseases. Kinase active sites share structural similarities making it difficult to specifically target one kinase, allosteri...
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Identifiers and source
- Literature Corpus work
- d6a43b65-e83d-5f84-8548-c41fd081f38b
- DOI
- 10.1101/2023.07.19.549709