Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Functional plasticity and evolutionary adaptation of allosteric regulation.

Proceedings of the National Academy of Sciences of the United States of America - 13 Oct 2020

Leander Megan, Yuan Yuchen, Meger Anthony, Cui Qiang, Raman Srivatsan

Abstract excerpt

Allostery is a fundamental regulatory mechanism of protein function. Despite notable advances, understanding the molecular determinants of allostery remains an elusive goal. Our current knowledge of allostery is principally shaped by a structure-centric view, which makes it difficult to understand the decentralized character of allostery. We present a function-centric approach using deep mutational scanning to...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adaptation, Physiological
Share to Allosteric Regulation

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Bacteria

Share to Bacterial Physiological Phenomena

Share to Epigenesis, Genetic

Share to Flow Cytometry

Share to Gene Expression Regulation, Enzymologic

Share to Molecular Dynamics Simulation

Source

Open in PubMed Open full text

Identifiers

PMID: 32999067
DOI: 10.1073/pnas.2002613117
PMCID: PMC7568325

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Functional plasticity and evolutionary adaptation of allosteric regulation.PMID 32999067Read ↗

Allostery is a widespread cause of loss-of-function variant pathogenicity.Semantic proximity Read ↗

Allostery is a widespread cause of loss-of-function variant pathogenicitySemantic proximity Read ↗

The origin of allosteric functional modulation: multiple pre-existing pathways.Semantic proximity Read ↗

What Mutagenesis Can and Cannot Reveal About Allostery.Semantic proximity Read ↗

AlloSigMA 2: paving the way to designing allosteric effectors and to exploring allosteric effects of mutations.Semantic proximity Read ↗

The allosteric landscape of the Src kinase.Semantic proximity Read ↗

Allosteric Modulation as a Unifying Mechanism for Receptor Function and Regulation.Semantic proximity Read ↗

Evolution and Engineering of Allosteric Regulation in Protein KinasesSemantic proximity Read ↗

Global mapping of the energetic and allosteric landscapes of protein binding domainsSemantic proximity Read ↗

AlloSigMA: allosteric signaling and mutation analysis server.Semantic proximity Read ↗

Deep mutational scanning and machine learning reveal structural and molecular rules governing allosteric hotspots in homologous proteins.Semantic proximity Read ↗

Epistasis shapes the fitness landscape of an allosteric specificity switch.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.