Article

Gut-Initiated Alpha Synuclein Fibrils Drive Parkinson's Disease Phenotypes: Temporal Mapping of non-Motor Symptoms and REM Sleep Behavior Disorder

2024-04-26

Abstract excerpt

Parkinson's disease (PD) is characterized by progressive motor as well as less recognized non-motor symptoms that arise often years before motor manifestation, including sleep and gastrointestinal disturbances. Despite the heavy burden on the patient's quality of life, these non-motor manifestations are poorly understood. To elucidate the temporal dynamics of the disease, we employed a mouse model involving inject...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 9d271a0a-8449-54fb-93fc-818cdc6d916b
DOI: 10.1101/2024.04.22.590542

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Gut-Initiated Alpha Synuclein Fibrils Drive Parkinson's Disease Phenotypes: Temporal Mapping of non-Motor Symptoms and REM Sleep Behavior DisorderDOI 10.1101/2024.04.22.590542Read

Gut-initiated alpha synuclein fibrils drive parkinsonism phenotypes: temporal mapping of REM sleep behavior disorder-like and other non-motor symptoms.Semantic proximity Read

Parkinson mice show functional and molecular changes in the gut long before motoric disease onsetSemantic proximity Read

Wake and non-rapid eye movement sleep dysfunction is associated with colonic neuropathology in Parkinson’s diseaseSemantic proximity Read

Modeling the pathological brain-gut axis in Parkinson’s disease using human iPSC derived brain-intestinal assembloidsSemantic proximity Read

A Summary of Phenotypes Observed in the In Vivo Rodent Alpha-Synuclein Preformed Fibril Model.Semantic proximity Read

A novel brainstem-targeted G51D α-synuclein fibril-injected mouse model exhibits sequential emergence of sleep and motor dysfunction.Semantic proximity Read

Distinct patterns of gene expression changes in the colon and striatum of young mice overexpressing alpha-synuclein support Parkinson Disease as a multi-system processSemantic proximity Read

Neurodegenerative disorders and gut-brain interactions.Semantic proximity Read

Age-dependent alpha-synuclein accumulation and aggregation in the colon of a transgenic mouse model of Parkinson’s diseaseSemantic proximity Read

Propagated α-synucleinopathy recapitulates REM sleep behaviour disorder followed by parkinsonian phenotypes in mice.Semantic proximity Read

α-Synuclein Pathology in Synucleinopathies: Mechanisms, Biomarkers, and Therapeutic ChallengesSemantic proximity Read