Article

Modeling the pathological brain-gut axis in Parkinson’s disease using human iPSC derived brain-intestinal assembloids

2026-02-10

Abstract excerpt

<h4>ABSTRACT</h4> Parkinson’ disease is increasingly recognized as a systemic disorder involving pathological communication along the brain–gut axis, yet the cellular mechanisms underlying inter-organ α-synuclein propagation remain poorly defined. Here, we establish a human induced pluripotent stem cell–derived brain–intestinal assembloid that integrates a developmentally specified medullary hindbrain organoid wi...

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Literature Corpus work: 3fe7ab23-fcb3-55c2-a9df-b515f6e4c92a
DOI: 10.64898/2026.02.07.704302

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