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Article

Age-dependent alpha-synuclein accumulation and aggregation in the colon of a transgenic mouse model of Parkinson’s disease

20 Jun 2018

Abstract excerpt

BACKGROUND: Parkinson's disease (PD) is one of the most common neurodegenerative diseases, neuropathologically characterized by misfolded protein aggregation, called Lewy bodies and Lewy neurites. PD is a slow-progressive disease with colonic dysfunction appearing in the prodromal stage and lasting throughout the course of the disease. METHODS: In order to study PD pathology in the colon, we examined the...

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PMID: 29988485
DOI: 10.1186/s40035-018-0118-8

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