Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A novel brainstem-targeted G51D α-synuclein fibril-injected mouse model exhibits sequential emergence of sleep and motor dysfunction.

Neuroscience research - 1 Mar 2026

Yasugaki Shinnosuke, Kaneko Ami, Okamura Hibiki, Hayakawa Hideki, Ikenaka Kensuke, Aguirre Cesar, Yanagisawa Masashi, Mochizuki Hideki, Baba Kousuke, Hayashi Yu

Abstract excerpt

Abnormal accumulation of alpha-synuclein (α-syn) is a central pathologic hallmark of synucleinopathies such as Parkinson's disease (PD), with rapid eye movement sleep behavior disorder (RBD) widely recognized as a prodromal manifestation of these disorders. Although several mouse models recapitulate the α-syn pathology, most fail to reproduce the brainstem-originating pathology propagation proposed by Braak and...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to alpha-Synuclein
Share to Brain Stem

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Disease Models, Animal

Share to Dopaminergic Neurons

Share to Mice, Inbred C57BL

Share to Mutation

Source

Identifiers

PMID: 41548850
DOI: 10.1016/j.neures.2026.105023

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A novel brainstem-targeted G51D α-synuclein fibril-injected mouse model exhibits sequential emergence of sleep and motor dysfunction.PMID 41548850Read ↗

Striatal-Inoculation of α-Synuclein Preformed Fibrils Aggravated the Phenotypes of REM Sleep without Atonia in A53T BAC-SNCA Transgenic Mice.Semantic proximity Read ↗

Structurally distinct α-synuclein fibrils induce robust parkinsonian pathology.Semantic proximity Read ↗

Propagated α-synucleinopathy recapitulates REM sleep behaviour disorder followed by parkinsonian phenotypes in mice.Semantic proximity Read ↗

G51D mutation of the endogenous rat <i>Snca</i> gene disrupts synaptic localisation of α-synuclein priming for Lewy-like pathologySemantic proximity Read ↗

Gut-Initiated Alpha Synuclein Fibrils Drive Parkinson's Disease Phenotypes: Temporal Mapping of non-Motor Symptoms and REM Sleep Behavior DisorderSemantic proximity Read ↗

Accelerated and Localized Synucleinopathy in a Hybrid Mouse Model: Implications for Positron Emission Tomography StudiesSemantic proximity Read ↗

Neuropathology in Mice Expressing Human α-SynucleinSemantic proximity Read ↗

Motor deficits and brain pathology in the Parkinson’s disease mouse model hA53TtgSemantic proximity Read ↗

Modeling Parkinson’s Disease With the Alpha-Synuclein ProteinSemantic proximity Read ↗

Neuropathology in mice expressing human alpha-synuclein.Semantic proximity Read ↗

A Summary of Phenotypes Observed in the In Vivo Rodent Alpha-Synuclein Preformed Fibril Model.Semantic proximity Read ↗

Bradykinesia and postural instability in a model of prodromal Synucleinopathy with α-Synuclein aggregation in the gigantocellular nucleiSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.