Article

YAP1 Activation by Human Papillomavirus E7 Promotes Basal Cell Identity in Squamous Epithelia

2021-11-10

Abstract excerpt

Persistent human papillomavirus (HPV) infection of stratified squamous epithelial cells causes nearly five percent of cancer cases worldwide. HPV-positive oropharyngeal cancers harbor few mutations in the Hippo signaling pathway compared to HPV-negative cancers at the same anatomical site, prompting the hypothesis that an HPV-encoded protein inactivates the Hippo pathway and activates the Hippo effector YAP1. The...

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Literature Corpus work: 9d22347f-77bb-5394-b901-666dc906a153
DOI: 10.1101/2021.11.10.468068

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YAP1 Activation by Human Papillomavirus E7 Promotes Basal Cell Identity in Squamous EpitheliaDOI 10.1101/2021.11.10.468068Read

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