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YAP1 activation by human papillomavirus E7 promotes basal cell identity in squamous epithelia

16 Feb 2022

Abstract excerpt

Persistent human papillomavirus (HPV) infection of stratified squamous epithelial cells causes nearly 5% of cancer cases worldwide. HPV-positive oropharyngeal cancers harbor few mutations in the Hippo signaling pathway compared to HPV-negative cancers at the same anatomical site, prompting the hypothesis that an HPV-encoded protein inactivates the Hippo pathway and activates the Hippo effector yes-associated...

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PMID: 35170430
DOI: 10.7554/elife.75466

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