Article

Hyperactivated YAP1 Drives an Invasive EMT Subtype of Cervical Squamous Cell Carcinoma

2026-01-19

Abstract excerpt

<h4>ABSTRACT</h4> Cervical cancer (CVC) is classically understood as an HPV-driven disease in which high-risk HPV infects cervical basal epithelial cells, induces neoplastic transformation, and drives upward epithelial expansion, pathogenic events underlying the success of cytology- and HPV-based screening. With widespread HPV vaccination and screening, the WHO has launched the CVC elimination initiative and beli...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 3fa38650-2236-5924-bb7b-d4f6b00f4cef
DOI: 10.64898/2026.01.18.700207

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Hyperactivated YAP1 Drives an Invasive EMT Subtype of Cervical Squamous Cell CarcinomaDOI 10.64898/2026.01.18.700207Read

The Hippo pathway transcription factors YAP and TAZ play HPV-type dependent roles in cervical cancerSemantic proximity Read

A Human Papillomavirus-Independent Cervical Cancer Animal Model Reveals Unconventional Mechanisms of Cervical CarcinogenesisSemantic proximity Read

Targeting HPV for the prevention, diagnosis, and treatment of cervical cancerSemantic proximity Read

<i>TAOK3</i> inhibition constrains invasion, potentiates paclitaxel, and reprograms the tumor microenvironment toward anti-tumor immunity in cervical cancerSemantic proximity Read

Spatiotemporally deciphering the mysterious mechanism of persistent HPV‐induced malignant transition and immune remodelling from HPV‐infected normal cervix, precancer to cervical cancer: Integrating single‐cell RNA‐sequencing and spatial transcriptomeSemantic proximity Read

<i>STK11</i> mutations and deletions define a distinct subtype of cervical adenocarcinomaSemantic proximity Read

Single-cell dissection of cellular and molecular features underlying human cervical squamous cell carcinoma initiation and progressionSemantic proximity Read

The Hallmarks of Cervical Cancer: Molecular Mechanisms Induced by Human PapillomavirusSemantic proximity Read

YAP1 Activation by Human Papillomavirus E7 Promotes Basal Cell Identity in Squamous EpitheliaSemantic proximity Read

Deciphering the cellular and molecular landscape of cervical cancer progression through single-cell and spatial transcriptomicsSemantic proximity Read

YAP1 activation by human papillomavirus E7 promotes basal cell identity in squamous epitheliaSemantic proximity Read

Identification of HPV oncogene and host cell differentiation associated cellular heterogeneity in cervical cancer via single-cell transcriptomic analysisSemantic proximity Read