Article

β-HPV 8E6 Dysregulates the Hippo Signaling Pathway and Induces Aneuploidy

2019-09-06

Abstract excerpt

<h4>ABSTRACT</h4> Beta genus human papillomaviruses (β-HPVs) are associated with cutaneous squamous cell carcinomas (cSCCs) in a subset of immunocompromised patients. Although β-HPVs are not necessary for tumor maintenance, they are hypothesized to destabilize the genome in the early stages of cancer development. Supporting this idea, β-HPV’s 8E6 protein attenuates p53 accumulation after failed cytokinesis. This...

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Literature Corpus work: ab29e857-585e-56d0-8912-e6f7c65d10e0
DOI: 10.1101/760439

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