The HPV8 E6 protein targets the Hippo and Wnt signaling pathways as part of its arsenal to restrain keratinocyte differentiation

Abstract excerpt

<h4>ABSTRACT</h4> Infections with β-genus HPVs cause hyperplastic cutaneous lesions. In individuals with the rare hereditary skin disease, epidermodysplasia verruciformis, such lesions can progress to cutaneous squamous cell carcinomas (cSCC). β-HPV infections may also underlie cSCC development in chronically immunosuppressed individuals. Despite their prevalence and disease association, these viruses are not as...

Topics

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• Cancer-related Molecular Pathways
• Cervical Cancer and HPV Research
• Head and Neck Cancer Studies
• Herpesvirus Infections and Treatments
• Molecular Biology Techniques and Applications
• NF-κB Signaling Pathways
• Viral-associated cancers and disorders
• Virus-based gene therapy research

Identifiers and source

Literature Corpus work

58b184ba-bdfe-56cb-9b09-6e703a6df0a1

DOI

10.1101/2023.06.22.546184