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What are the essential determinants of human papillomavirus carcinogenesis?

4 Oct 2024

Abstract excerpt

Human papillomavirus (HPV) infection is the leading viral cause of cancer. Over the past several decades, research on HPVs has provided remarkable insight into human cell biology and into the pathology of viral and non-viral cancers. The HPV E6 and E7 proteins engage host cellular proteins to establish an environment in infected cells that is conducive to virus replication. They rewire host cell signaling...

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PMID: 39365046
DOI: 10.1128/mbio.00462-24

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