Article

Target-specific requirements for RNA interference can arise through restricted RNA amplification despite the lack of specialized pathways

2023-02-08

Abstract excerpt

<h4>ABSTRACT</h4> Since double-stranded RNA (dsRNA) is effective for silencing a wide variety of genes, all genes are typically considered equivalent targets for such RNA interference (RNAi). Yet, loss of some regulators of RNAi in the nematode C. elegans can selectively impair the silencing of some genes. Here we show that such selective requirements can be explained by an intersecting network of regulators act...

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Literature Corpus work: 9cddf87a-019a-5266-81f6-e1472d1477ee
DOI: 10.1101/2023.02.07.527351

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