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Article

A-to-I RNA editing promotes developmental stage-specific gene and lncRNA expression.

Genome research - 1 Mar 2017

Goldstein Boaz, Agranat-Tamir Lily, Light Dean, Ben-Naim Zgayer Orna, Fishman Alla, Lamm Ayelet T

Abstract excerpt

A-to-I RNA editing is a conserved widespread phenomenon in which adenosine (A) is converted to inosine (I) by adenosine deaminases (ADARs) in double-stranded RNA regions, mainly noncoding. Mutations in ADAR enzymes in Caenorhabditis elegans cause defects in normal development but are not lethal as in human and mouse. Previous studies in C. elegans indicated competition between RNA interference (RNAi) and RNA...

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Identifiers

PMID: 28031250
DOI: 10.1101/gr.211169.116
PMCID: PMC5340973

Genes

ADAR

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