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Sequential action of the nuclear Argonautes HRDE-1 and NRDE-3 promotes global transcriptional silencing during starvation in the nascent <i>C. elegans</i> germline

2025-06-25

Abstract excerpt

In C. elegans , if embryos hatch into an environment lacking nutrients the primordial germ cells (PGCs) will arrest mRNA transcription and enter quiescence until food becomes available. Our previous work had shown that the global transcriptional silencing (GTS) that occurs in PGCs during L1 starvation requires a “hyperdeposition” of the repressive histone mark H3K9me3 in germline chromatin. Hyperdeposition is def...

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Literature Corpus work
2b72e0a4-dd85-5ad7-9211-fa8ef7789342
DOI
10.1101/2025.06.25.661390
Open publication

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Sequential action of the nuclear Argonautes HRDE-1 and NRDE-3 promotes global transcriptional silencing during starvation in the nascent <i>C. elegans</i> germlineDOI 10.1101/2025.06.25.661390
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