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Specific immune modulation of experimental colitis drives enteric alpha-synuclein accumulation and triggers age-related Parkinson-like brain pathology

2020-11-03

Abstract excerpt

<title>Abstract</title> <p><bold>Background :</bold> Intraneuronal accumulation of a-synuclein (αSyn) is key in Parkinson’s disease (PD) pathogenesis. The pathogenic process is suggested to begin in the enteric nervous system decades before diagnosis of PD and then propagate into the brain. The triggers for these events are unclear but, in some patients, colitis might play a critical role. <bold>Methods :</bold>...

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Literature Corpus work
9cdb77f2-0d52-5f57-8770-7e74bfd85478
DOI
10.21203/rs.3.rs-100199/v1
Open publication

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Specific immune modulation of experimental colitis drives enteric alpha-synuclein accumulation and triggers age-related Parkinson-like brain pathologyDOI 10.21203/rs.3.rs-100199/v1
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