Article

Microbiota-dependent T-cell response to α-synuclein-derived antigens triggers the development of hypersensitivity and neuroinflammation associated with Parkinson's Disease

2024-08-16

Abstract excerpt

<title>Abstract</title> <p><bold>Background</bold>. Previous evidence has shown that both the T-cell response and the microbiota play fundamental roles on the development of Parkinson's Disease (PD), which involves motor impairment and chronic pain. PD physiopathology involves the generation of pathogenic forms of α-synuclein (aSyn), which are associated with abnormal post-translational modifications and aggregat...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 0df81037-4c67-503f-815d-31ff1feadc1b
DOI: 10.21203/rs.3.rs-4707767/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Microbiota-dependent T-cell response to α-synuclein-derived antigens triggers the development of hypersensitivity and neuroinflammation associated with Parkinson's DiseaseDOI 10.21203/rs.3.rs-4707767/v1Read

Escherichia coli triggers α-synuclein pathology in the LRRK2 transgenic mouse model of PDSemantic proximity Read

Functional Metagenomic Analysis Reveals Early Gut Microbiota Alterations in Alpha-Synuclein Transgenic Mice: Insights into Parkinson’s Disease ProgressionSemantic proximity Read

Alpha-synuclein overexpression can drive microbiome dysbiosis in miceSemantic proximity Read

Alpha synuclein overexpression can drive microbiome dysbiosis in miceSemantic proximity Read

Specific immune modulation of experimental colitis drives enteric alpha-synuclein accumulation and triggers age-related Parkinson-like brain pathologySemantic proximity Read

Neuromicrobiology of Neurodegenerative Diseases:Semantic proximity Read

Microbiome, Parkinson’s Disease and Molecular MimicrySemantic proximity Read

Interaction of an α-synuclein epitope with HLA-DRB1*15:01 triggers enteric features in mice reminiscent of prodromal Parkinson’s diseaseSemantic proximity Read

Effects of Probiotics on peripheral immunity in Parkinson’s Disease: a pilot, randomized, placebo-controlled study to evaluate the efficacy of Probiotics in modulating peripheral immunity in subjects with Parkinson’s DiseaseSemantic proximity Read

Enriched environmental conditions modify the gut microbiome composition and fecal markers of inflammation in Parkinson’s diseaseSemantic proximity Read

Exploring human-genome gut-microbiome interaction in Parkinson’s diseaseSemantic proximity Read

Upregulation of α-synuclein following immune activation: Possible trigger of Parkinson's diseaseSemantic proximity Read